Novel water‐in‐oil emulsion prevents skin damage

Source: mma23 –

Particulate matter (PM), such as air pollutants and pollens, are known to cause skin aging through skin inflammation. It is important to develop formulations, which protect the skin from PM. Researchers from Pola Chemical Industries in Japan previously developed a conventional water‐in‐oil emulsion with a synthetic surfactant, distearyldimonium chloride, modified bentonite (C‐W/O), which protects skin from allergens. In the present study, they developed a novel water‐in‐oil emulsion with a natural surfactant, lecithin, modified bentonite (N‐W/O).

Microarray analysis performed

The microarray analysis was performed using total RNA extracted from a reconstructed human epidermis (RHE) stimulated with urban aerosols or cedar pollen for six hours in order to develop an epidermal inflammation model by PM for the evaluation of topical formulations. The researchers then compared the efficacy of N‐W/O and C‐W/O to prevent epidermal degradation. Tissues and culture media were collected 24 hours after the urban aerosol or cedar pollen stimulation for a histological assay, and the quantification of MMP1 and CXCL8 secretion.

According to the researchers, the results showed that N‐W/O made using natural surfactant is useful at protecting skin from PM, such as urban aerosols and cedar pollen.


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