Anti-dandruff active promotes healthy scalp microbiome

Portrait of a woman with bright colored flying hair, all shades of purple. Hair coloring, beautiful lips and makeup. Hair fluttering in the wind. Sexy girl with short hair
Portrait of a woman with bright colored flying hair, all shades of purple. Hair coloring, beautiful lips and makeup. Hair fluttering in the wind. Sexy girl with short hair


In a clinical study, Symrise has found additional positive effects for “Crinipan PMC green”, its novel, plant-based anti-dandruff active. The new molecule is as effective against dandruff as traditional ingredients, and also helps to promote healthy scalp. Application of the ingredient by test subjects with dandruff resulted in a healthier ratio of two dominant species of scalp bacteria. This finding is based on ex vivo samples, that the company´s researchers took from the scalp of study participants, before and after a 30-day application of the active ingredient. The substance is suitable for use in many types of dandruff control and scalp care products.

The company has incorporated modern research technologies on scalp microbiome into its clinical studies. Contemporary scientific literature reports that besides of the well discussed relevance of Malassezia yeast in dandruff formation, also bacteria seem to play a bigger role than assumed in the past. The ratio of propionibacteria to staphylococci on healthy scalp favors propionibacteria, while the opposite applies to scalp with dandruff. The company has now discovered that application of their ingredient is supporting a favourable shift in this bacterial balance promoting a healthier scalp. At the same time, the researchers observed the opposite effect on the scalps treated with a placebo product.

Activated by enzymes

The active also stands out with its innovative mode of action to target dandruff. Malassezia, known as one of the main causes for dandruff on scalp, activates the ingredient with its enzymes. The company has already demonstrated the ingredient´s effectiveness in a clinical shampoo study, demonstrating comparable efficacy known from conventional actives like climbazole. The novel ingredient is receiving a great deal of attention, for example by winning the renowned BSB Award 2020 in the category Most Innovative Active Ingredient/Scalp, Barrier, Redness.

“Consumers will be able to use an ingredient that is effective against dandruff as well as supporting healthy scalp,” says Dr. Florian Genrich, Senior Global Product Manager Skin Protection in the Cosmetic Ingredients division. “We have once again proven our power to innovate, which we base upon more than 45 years of experience in the field of Micro Protection.”

Sustainably produced using plant-based raw materials

Another unique characteristic of this ingredient lies in its eco-friendly production process, based on 100% renewable raw materials. The company also fulfils consumers’ desire for cosmetics featuring natural ingredients that deliver effectiveness known from conventional products.

“With this ingredient, we are offering an eco-friendly alternative to traditional anti-dandruff actives,” says Dr. Christin Koch, Head of Microbiological Research in the Global Innovation Cosmetic Ingredients Division. “We plan to develop more and more green products in the future, which will allow us to contribute to climate protection and take responsibility for future generations.”


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